BTW, the sample I bought a couple of months ago is significantly darker than the panels I received but that worked to my advantage. The only thing I would ask Naturewall to change is to add even more staples along the strips or glue/bond them as when cutting the various cutouts, I had to glue a few pieces that came adrift. A wall bracket for the 65” TV and Sonos Arc and a floating TV cabinet finished the look. It can be fairly pricey so I went for a solid block of four panels in the middle of the TV wall, painting the rest of the wall a complimentary dark grey. The panels are really high quality and arrived in good condition. DIY would have taken me probably four times as long and wouldn’t have looked anywhere near as good (shame I can’t post photos here). The grain is fairly pronounced and adds to a super high-end look. I decided to go with smoked oak 3m panels in the end as we have 2.8m ceiling heights, so glad I did - these look significantly better than a DIY solution. A few people on social media said to DIY and buy wood strips and paint/stain them. of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USAĬenter for RNA Biology, University of Rochester Medical Center, Rochester, NY, USAĭept.I’ve been looking at acoustic wood paneling for about six months since moving to our new house. StemiRNA Therapeutics Inc., Shanghai, ChinaĪng Lin, Congcong Xu, Xiaopin Ma, Fanfan Zhao, Huiling Jiang, Chunxiu Chen, Haifa Shen, Hangwen Li & Yujian Zhangĭept. He Zhang, Liang Zhang, Kaibo Liu & Liang Huang School of EECS, Oregon State University, Corvallis, OR, USA He Zhang, Liang Zhang, Ziyu Li, Kaibo Liu, Boxiang Liu & Liang Huang These authors contributed equally: He Zhang, Liang Zhang, Ang Lin, Congcong Xu, Liang Huang of Pharmacy, National University of Singapore, Singapore, Singapore Present address: Vaccine Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China Our work is a timely tool not only for vaccines but also for mRNA medicine encoding all therapeutic proteins (e.g., monoclonal antibodies and anti-cancer drugs (7, 8)). This surprising result reveals the great potential of principled mRNA design, and enables the exploration of previously unreachable but highly stable and efficient designs. On both COVID-19 and varicella-zoster virus mRNA vaccines, LinearDesign substantially improves mRNA half-life and protein expression, and dramatically increases antibody titer by up to 128× in vivo, compared to the codon-optimization benchmark. Our algorithm LinearDesign takes only 11 minutes for the Spike protein, and can jointly optimize stability and codon usage. Here we provide a simple and unexpected solution using a classical concept in computational linguistics, where finding the optimal mRNA sequence is akin to identifying the most likely sentence among similar sounding alternatives (6). However, due to synonymous codons, the mRNA design space is prohibitively large (e.g., ~10 632 candidates for the SARS-CoV-2 Spike protein), which poses insurmountable computational challenges. Therefore, a principled mRNA design algorithm must optimize both structural stability and codon usage. Previous work showed that increasing secondary structure lengthens mRNA half-life, which, together with optimal codons, improves protein expression (5). Messenger RNA (mRNA) vaccines are being used to contain COVID-19 (1, 2, 3), but still suffer from the critical limitation of mRNA instability and degradation, which is a major obstacle in the storage, distribution, and efficacy of the vaccine products (4).
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